PRKN ELISA kits are immunoassay tools for the measurement of the protein parkin RBR E3 ubiquitin protein ligase, which is encoded by the PRKN gene in humans. Functionally, this protein is reported to function within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. The canonical protein structure is reported to have an amino acid length of 465 residues, a mass of 51.6 kDa, and is a member of the RBR protein family. It is known to be localized in the nucleus, mitochondria, ER, and cytoplasm and is reported to be highly expressed in the brain including the substantia nigra. As many as 8 protein isoforms have been reported. The protein has been noted to be post-translationally ubiquitinated and phosphorylated. The PRKN gene has been associated with the disease, Parkinson disease. Other alias names for this target include LPRS2, PARK2, PDJ, E3 ubiquitin-protein ligase parkin, Parkinson disease (autosomal recessive, juvenile) 2, parkin, and AR-JP.
The detection range for different PRKN ELISA kits can vary, with some assays measuring target concentrations as low as 1 ng/L and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.