HPSE ELISA kits are immunoassay tools for the measurement of the protein heparanase, which is encoded by the HPSE gene in humans. Functionally, this protein is a reported endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. The canonical protein structure is reported to have an amino acid length of 543 residues, a mass of 61.1 kDa, and is a member of the Glycosyl hydrolase 79 protein family. It is known to be localized in the nucleus, lysosomes, membrane, and is secreted and is reported to be highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. As many as 4 protein isoforms have been reported. The protein has been noted to be post-translationally N-glycosylated and cleaved. Other alias names for this target include HPA1, HPR1, HPSE1, HSE1, endo-glucoronidase, heparanase-1, and HPA.
The detection range for different HPSE ELISA kits can vary, with some assays measuring target concentrations as low as 15.6 pg/mL and as high as 100 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.