Anti-CRIPTO antibodies are used in the immunodetection of the protein cripto, EGF-CFC family member. In humans, the canonical protein has a reported length of 188 amino acid residues and a mass of 21.2 kDa. Its subcellular localization is in the cell membrane and is secreted. It is found to be highly expressed in gastric and colorectal carcinomas than in their normal counterparts. A member of the EGF-CFC (Cripto-1/FRL1/Cryptic) protein family, CRIPTO is known to be involved with cell differentiation and TNF-mediated cellular signaling pathways. Post-translational modifications have been described, including protein cleavage and glycosylation.
The TDGF1 marker can be used to identify Corticomedullary Thymic Epithelial Cells.* Synonyms for this target antigen include CR-1, CRGF, CRIPTO, cripto-1 growth factor, epidermal growth factor-like cripto protein CR1, and CR. Over 70 citations in the literature describe the use of TDGF1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4