Anti-ATP2B2 antibodies are used in the immunodetection of the protein ATPase plasma membrane Ca2+ transporting 2. In humans, the canonical protein has a reported length of 1243 amino acid residues and a mass of 136.9 kDa. Its subcellular localization is in the cell membrane. Up to 8 different isoforms have been reported for this protein. It is reported to be mainly expressed in the brain cortex. A member of the Cation transport ATPase (P-type) (TC 3.A.3) protein family, ATP2B2 is known to be involved with brain development and the transport of ions. Synonyms for this target antigen include PMCA2, PMCA2a, PMCA2i, plasma membrane calcium-transporting ATPase 2, ATPase, Ca++ transporting, plasma membrane 2, and DFNA82. ATP2B2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 120 citations in the literature describe the use of ATP2B2 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.