Anti-HRH2 antibodies are used in the immunodetection of the protein histamine receptor H2. In humans, the canonical protein has a reported length of 359 amino acid residues and a mass of 40.1 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the duodenum and small intestine. A member of the G-protein coupled receptor 1 protein family, HRH2 is known to be involved with chemical synaptic transmission and immune response pathways. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include HH2R, histamine H2 receptor, gastric receptor 1, gastric receptor I, and H2R. HRH2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of HRH2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.