What are UGT1A1 antibodies?
Anti-UGT1A1 antibodies are immunoglobulins that specifically recognize and bind UGT1A1, the gene encoding UDP-glucuronosyltransferase 1A1 in humans. These antibodies are used for immunodetection across general sample types such as tissue samples, cell lysates, and cultured cells. UGT1A1 conjugates lipophilic substrates, including bilirubin and endogenous estrogens, with glucuronic acid to increase their water solubility and facilitate excretion into bile or urine. Because impaired UGT1A1 activity underlies bilirubin-clearance disorders such as Gilbert's and Crigler-Najjar syndromes and influences drug metabolism more broadly, the enzyme is studied in hepatology and pharmacology research.
Catalog highlights and purchasing considerations
About the Biocompare UGT1A1 catalog
The Biocompare antibody search tool lists anti-UGT1A1 antibodies from a range of suppliers, spanning polyclonal and monoclonal formats validated across multiple applications. Western blot, immunohistochemistry, and immunocytochemistry are the most common validated applications among these products. In addition, the UGT1A1 antibodies mentioned here have been cited across a range of hepatology and pharmacology research, including studies on drug-drug interactions affecting hepatic metabolism, bilirubin clearance and nuclear receptor regulation, and estrogen receptor glycosylation in breast cancer drug resistance.
Considerations when choosing a UGT1A1 antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria include clonality (monoclonal versus polyclonal), host species, species reactivity, and the choice of conjugate or label suited to the intended detection method. Supplier-provided validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, or knockout and knockdown controls, is widely regarded as the most reliable final check before purchase.