Anti-GAN antibodies are used in the immunodetection of the protein gigaxonin. In humans, the canonical protein has a reported length of 597 amino acid residues and a mass of 67.6 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in the brain, heart and muscle. GAN is a suspected cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include GIG, KLHL16, epididymis secretory sperm binding protein, kelch-like family member 16, kelch-like protein 16, and GAN1.