Anti-Paxillin antibodies are used for the immunodetection of the protein encoded by the PXN gene. In humans, the canonical protein has a reported length of 591 amino acid residues and a mass of 64.5 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of the Paxillin protein family, it is known to be a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include testicular tissue protein Li 134. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.