Anti-TMEM259 antibodies are used in the immunodetection of the protein transmembrane protein 259. In humans, the canonical protein has a reported length of 620 amino acid residues and a mass of 67.9 kDa. Its subcellular localization is in the ER. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Membralin protein family, Tmem259 is suspected to have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include membralin and aspecific BCL2 ARE-binding protein 1. TMEM259 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is the most common application for the Tmem259 antibodies listed below. Immunofluorescence and Immunohistochemistry are also common applications.