Anti-SDE2 antibodies are used in the immunodetection of the protein SDE2 telomere maintenance homolog. In humans, the canonical protein has a reported length of 451 amino acid residues and a mass of 49.7 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the SDE2 protein family, SDE2 is reported to inhibit DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. Post-translational modifications have been described, including ubiquitination and protein cleavage. Synonyms for this target antigen include UPF0667 protein C1orf55, protein SDE2 homolog, replication stress response regulator SDE2, and splicing regulator SDE2. SDE2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some SDE2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.