Anti-ETNPPL antibodies are used in the immunodetection of the protein ethanolamine-phosphate phospho-lyase. In humans, the canonical protein has a reported length of 499 amino acid residues and a mass of 55.7 kDa. Its subcellular localization is in the mitochondria. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the salivary gland, hippocampus, cerebral cortex, cerebellum, and caudate. A member of the Class-III pyridoxal-phosphate-dependent aminotransferase protein family, ETNPPL is known to catalyze the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde. The ETNPPL marker can be used to identify Gray Matter Astrocytes.* Synonyms for this target antigen include alanine--glyoxylate aminotransferase 2-like 1. ETNPPL gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4