Anti-HSPB6 antibodies are used in the immunodetection of the protein heat shock protein family B (small) member 6. In humans, the canonical protein has a reported length of 160 amino acid residues and a mass of 17.1 kDa. Its subcellular localization is in the nucleus, cytoplasm, and is secreted. It is notably expressed in many tissues, such as in adipose tissue and adrenal gland. A member of the Small heat shock protein (HSP20) protein family, HSPB6 is known to be involved with the regulation of angiogenesis. Post-translational modifications have been described, including phosphorylation. The HSPB6 marker can be used to identify Type 1 Thymic Fibroblasts.* Synonyms for this target antigen include epididymis luminal protein 55, epididymis secretory sperm binding protein, heat shock 20 kDa-like protein p20, heat shock protein family B (small) member B6, and heat shock protein beta-6. HSPB6 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4