Anti-USP8 antibodies are used in the immunodetection of the protein ubiquitin specific peptidase 8. In humans, the canonical protein has a reported length of 1118 amino acid residues and a mass of 127.5 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the bronchus, urinary bladder, and appendix. A member of the Peptidase C19 protein family, USP8 is a known hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Synonyms for this target antigen include PITA4, SPG59, UBPY, ubiquitin carboxyl-terminal hydrolase 8, deubiquitinating enzyme 8, and HumORF8. USP8 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of USP8 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.