SMYD3 encodes the human gene, SET and MYND domain containing 3. It may also be known as: Histone-lysine N-methyltransferase SMYD3; Zinc finger MYND domain-containing protein 1; Histone-lysine N-methyltransferase SMYD3 ; SET and MYND domain-containing protein 3; KMT3E; ZMYND1; ZNFN3A1; bA74P14.1. The encoded protein is an enzyme with an amino acid length of 428 and a mass of 49.1 kDa. Other isoforms may exist. SMYD3 is a member of the Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family. Homologs of this gene exist in other organisms, including: Mouse, Rat, Zebrafish, Frog, Chicken.