Anti-SMYD3 antibodies are used in the immunodetection of the protein SET and MYND domain containing 3. In humans, the canonical protein has a reported length of 428 amino acid residues and a mass of 49.1 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be expressed in skeletal muscles and testis. A member of the Histone-lysine methyltransferase protein family, it is known to be involved with the regulation of transcription. Synonyms for this target antigen include SET and MYND domain-containing protein 3, zinc finger MYND domain-containing protein 1, zinc finger protein, subfamily 3A (MYND domain containing), 1, and histone-lysine N-methyltransferase SMYD3.