Anti-KNSTRN antibodies are used in the immunodetection of the protein kinetochore localized astrin (SPAG5) binding protein. In humans, the canonical protein has a reported length of 316 amino acid residues and a mass of 35.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be widely expressed including in skin. KNSTRN is an important component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. The KNSTRN gene has been associated with the disease, Roifman-Chitayat syndrome. Synonyms for this target antigen include TRAF4 associated factor 1, kinastrin, kinetochore-localized astrin-binding protein, putative TRAF4-associated factor 1, and small kinetochore-associated protein. KNSTRN gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of KNSTRN antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunocytochemistry and Immunohistochemistry are also common applications.