Anti-SCN5A antibodies are used in the immunodetection of the protein sodium voltage-gated channel alpha subunit 5. In humans, the canonical protein has a reported length of 2016 amino acid residues and a mass of 226.9 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 6 different isoforms have been reported for this protein. A member of the Sodium channel (TC 1.A.1.10) protein family, SCN5A is known to mediate the voltage-dependent sodium ion permeability of excitable membranes. Post-translational modifications have been described, including glycosylation, ubiquitination and phosphorylation.
The SCN5A marker can be used to identify Amygdala Excitatory Neurons.* Synonyms for this target antigen include CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, and CDCD2. SCN5A gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 350 citations in the literature describe the use of SCN5A antibodies in research. Immunohistochemistry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.
*HuBMAP Human Reference Atlas v1.4