Anti-PDC antibodies are used in the immunodetection of the protein phosducin. In humans, the canonical protein has a reported length of 246 amino acid residues and a mass of 28.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the retina and testis. A member of the Phosducin protein family, PDC is believed to participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Post-translational modifications have been described, including phosphorylation.
The PDC marker can be used to identify Eye Photoreceptor Cells.* Synonyms for this target antigen include PHD, PhLOP, PhLP, 33 kDa phototransducing protein, G beta gamma binding protein, and MEKA. PDC gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Western Blot is a widely used application for the PDC antibodies listed below. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4