Anti-LRRC8E antibodies are used in the immunodetection of the protein leucine rich repeat containing 8 VRAC subunit E. In humans, the canonical protein has a reported length of 796 amino acid residues and a mass of 90.2 kDa. Its subcellular localization is in the ER, lysosomes, and cell membrane. A member of the LRRC8 protein family, LRRC8E is reported to be a non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include leucine rich repeat containing 8 family member E, leucine-rich repeat-containing protein 8E, and volume-regulated anion channel subunit LRRC8E. LRRC8E gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. ELISA is the most common application for the LRRC8E antibodies listed below. Western Blot and Immunohistochemistry are also common applications.