Anti-Cyclin D2 antibodies are used in the immunodetection of the protein encoded by the CCND2 gene. In humans, the canonical protein has a reported length of 289 amino acid residues and a mass of 33.1 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Cyclin protein family, it is a reported regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Post-translational modifications have been described, including ubiquitination and phosphorylation. Other names for this target antigen include MPPH3, G1/S-specific cyclin-D2, and KIAK0002.