Anti-RNF146 antibodies are used in the immunodetection of the protein ring finger protein 146. In humans, the canonical protein has a reported length of 359 amino acid residues and a mass of 39 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. RNF146 is known to be involved with the Wnt signaling pathway. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include RING-type E3 ubiquitin transferase RNF146, dactylidin, iduna, and E3 ubiquitin-protein ligase RNF146. RNF146 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.