Anti-EIF2B5 antibodies are used in the immunodetection of the protein eukaryotic translation initiation factor 2B subunit epsilon. In humans, the canonical protein has a reported length of 721 amino acid residues and a mass of 80.4 kDa. It is notably widely expressed in many tissue types. A member of the EIF-2B gamma/epsilon subunits protein family, EIF2B5 is known to catalyze the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Post-translational modifications have been described, including ubiquitination and phosphorylation. The EIF2B5 gene has been associated with the disease, Leukodystrophy with vanishing white matter. Synonyms for this target antigen include CLE, EIF-2B, EIF2Bepsilon, LVWM, VWM5, and CACH. EIF2B5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of EIF2B5 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.