Anti-OTP antibodies are used in the immunodetection of the protein orthopedia homeobox. In humans, the canonical protein has a reported length of 325 amino acid residues and a mass of 34.2 kDa. Its subcellular localization is in the nucleus. It is notably expressed in the hypothalamus. A member of the Paired homeobox protein family, OTP is suspected to be involved in the differentiation of hypothalamic neuroendocrine cells. The OTP marker can be used to identify Pons Splatter Neurons, Brain Splatter Neurons, Hypothalamus Splatter Neurons, and Gray Matter Splatter Neurons.* Synonyms for this target antigen include homeobox protein orthopedia and orthopedia homolog. OTP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4