Anti-SALL4 antibodies are immunoglobulins that specifically recognize and bind SALL4, the gene encoding Sal-like protein 4 in humans. In research applications, these antibodies are used to detect SALL4 in tissue samples, cell lysates, and cultured cells. SALL4 is a transcription factor that plays a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. Because SALL4 is re-expressed in germ cell tumors and some other malignancies but largely absent from adult somatic tissue, it is widely used as a diagnostic marker in surgical pathology.
Catalog highlights and purchasing considerations
About the Biocompare SALL4 antibody catalog
The Biocompare antibody search tool lists anti-SALL4 antibodies from a range of suppliers, spanning unconjugated and fluorophore- or enzyme-conjugated formats. Immunohistochemistry is the most common validated application among these listings, followed by western blot and immunofluorescence. Several SALL4 antibodies mentioned here have been cited across a range of developmental biology research, including IRAK4-mediated constraints on cell fate reprogramming, characterization of a SMARCA4-deficient thoracic tumor cell line, and NFYA-directed chromatin accessibility during male meiotic entry.
Considerations when choosing a SALL4 antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria warrant consideration, including clonality (monoclonal versus polyclonal), host species, species reactivity, and conjugate or label choice suited to the detection method. Supplier validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, and knockout or knockdown controls, should also be carefully reviewed before purchase.