Anti-AGER antibodies are used in the immunodetection of the protein advanced glycosylation end-product specific receptor. In humans, the canonical protein has a reported length of 404 amino acid residues and a mass of 42.8 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 1 different isoforms have been reported for this protein. It is notably expressed in the adrenal gland and lung. AGER is known to be involved with receptor-mediated signaling pathways and inflammatory response pathways. Post-translational modifications have been described, including glycosylation, ubiquitination and phosphorylation. The AGER marker can be used to identify Alveolar Type I Cells.* Synonyms for this target antigen include SCARJ1, sRAGE, receptor for advanced glycation end-products, and RAGE. AGER gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4