Anti-RIC3 antibodies are used in the immunodetection of the protein RIC3 acetylcholine receptor chaperone. In humans, the canonical protein has a reported length of 369 amino acid residues and a mass of 41.1 kDa. Its subcellular localization is in the ER and Golgi. Up to 5 different isoforms have been reported for this protein. It is widely expressed across many tissues, with high levels in muscle, brain, heart, pancreas and testis. A member of the Ric-3 protein family, RIC3 is reported to be a molecular chaperone, which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. Synonyms for this target antigen include resistance to inhibitors of cholinesterase 3, resistance to inhibitors of cholinesterase 3-like protein, resistant to inhibitor of cholinesterase 3, and protein RIC-3. RIC3 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some RIC3 antibodies may have been used in research and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.