Anti-VPO antibodies are used in antigen-specific immunodetection in biological samples. The target VPO is a known alias name of the protein peroxidasin, encoded by the PXDN gene in humans. This 1479-amino acid residue protein is known to catalyze the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer. It is localized to the ER, extracellular matrix, and is secreted of the cell and features N-glycosylated and cleaved post-translational modifications. In terms of tissue expression, it is noted to be expressed at higher levels in the heart, lung, ovary, spleen, intestine and placenta, and at lower levels in the liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Other synonyms for VPO include ASGD7, COPOA, and D2S448. A number of VPO antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.