SPL is an alias for the gene, Sphingosine-1-phosphate lyase 1, in humans. Other names include: SP-lyase 1 1; hSPL; Sphingosine-1-phosphate aldolase; S1PL. The encoded protein is an enzyme with an amino acid length of 568 and a mass of 63.5 kDa. Other isoforms may exist. SPL is a member of the Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily. This gene shares homology with other species, including: Rat, Zebrafish, Frog, Chicken.