Anti-LRRC8B antibodies are used in the immunodetection of the protein leucine rich repeat containing 8 VRAC subunit B. In humans, the canonical protein has a reported length of 803 amino acid residues and a mass of 92.4 kDa. Its subcellular localization is in the ER and cell membrane. A member of the LRRC8 protein family, LRRC8B is reported to be a non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include TALRRP, volume-regulated anion channel subunit LRRC8B, T-cell activation leucine repeat-rich protein, epididymis secretory sperm binding protein, and TA-LRRP. LRRC8B gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Western Blot is the most common application for the LRRC8B antibodies listed below. Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.