Anti-ESAM antibodies are used in the immunodetection of the protein endothelial cell adhesion molecule. In humans, the canonical protein has a reported length of 390 amino acid residues and a mass of 41.2 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in endothelial cells. ESAM is known to be involved with cell adhesion and protein localization. Post-translational modifications have been described, including glycosylation.
The ESAM marker can be used to identify Blood Vessel Endothelial Cells.* Synonyms for this target antigen include 2310008D05Rik, HUEL (C4orf1)-interacting protein, LP4791 protein, and endothelial cell-selective adhesion molecule. ESAM gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 100 citations in the literature describe the use of ESAM antibodies in research. Flow Cytometry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.
*HuBMAP Human Reference Atlas v1.4