Anti-AME antibodies are used in antigen-specific immunodetection in biological samples. The target AME is a known alias name of the protein hydroxysteroid 11-beta dehydrogenase 2, encoded by the HSD11B2 gene in humans. This 405-amino acid residue protein is known to catalyze the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). It is localized to the ER of the cell. In terms of tissue expression, it is reported to be expressed in the kidney, placenta, pancreas, prostate, ovary, small intestine and colon, and in lower levels in the spleen and testis. Other synonyms for AME include AME1 and HSD11K. Indicated applications for AME antibodies listed below include ELISA, Flow Cytometry, Western Blot, Immunocytochemistry, and Immunohistochemistry.