Anti-TLL antibodies are used in antigen-specific immunodetection in biological samples. The target TLL is a known alias name of the protein nuclear receptor subfamily 2 group E member 1, encoded by the NR2E1 gene in humans. This 385-amino acid residue protein is reported to be an orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). It is localized to the nucleus of the cell. In terms of tissue expression, it is reported to have brain specific expression.