Anti-SPARC like 1 antibodies are used for the immunodetection of the protein encoded by the SPARCL1 gene. In humans, the canonical protein has a reported length of 664 amino acid residues and a mass of 75.2 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the SPARC protein family, it is known to be involved with signal transduction pathways. Post-translational modifications have been described, including O-glycosylation.
The SPARC like 1 marker can be used to characterize Blood Vessel Endothelial Cells and Type 1 Thymic Fibroblasts.* Other names for this target antigen include MAST9, PIG33, SC1, SPARC-like protein 1, SPARC-like 1 (hevin), and MAST 9. Gene orthologs have been identified in the mouse, rat, bovine, chimpanzee and chicken species. A number of SPARC like 1 antibodies have been mentioned in research publications and have associated citations. ELISA is a widely used application for these antibodies. Western Blot, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4