Anti-CENH3 antibodies enable researchers to detect and measure the CENH3 antigen in biological samples. This target is a reported synonym of the CENPA gene, which encodes centromere protein A. This protein is known to function in cell division, among other biological roles. The human version of CENH3 has a canonical amino acid length of 140 residues and a protein mass of 16 kilodaltons, although 2 isoforms have been identified. It is reported to be localized in the nucleus of cells and notably expressed in many tissues, such as the cervix, tonsil, and bone marrow. CENH3 is a member of the Histone H3 protein family.