Anti-IGSF8 antibodies are used in the immunodetection of the protein immunoglobulin superfamily member 8. In humans, the canonical protein has a reported length of 613 amino acid residues and a mass of 65 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in the brain, kidney, testis, liver and placenta with moderate expression in all other tissues. IGSF8 is believed to play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include glu-Trp-Ile EWI motif-containing protein 2, keratinocytes-associated transmembrane protein 4, prostaglandin regulatory-like protein, and CD81 partner 3. IGSF8 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.