Anti-MMRN1 antibodies are used in the immunodetection of the protein multimerin 1. In humans, the canonical protein has a reported length of 1228 amino acid residues and a mass of 138.1 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the skin, gallbladder, cerebral cortex, breast, and bone marrow. MMRN1 is known to be involved with cell adhesion. Post-translational modifications have been described, including N-glycosylation.
The MMRN1 marker can be used to identify Lymphatic Endothelial Cells, Respiratory Lymphatic Vessel Endothelial Cells, Respiratory Vein Endothelial Cells, and Lymphatic Vessel Endothelial Cells.* Synonyms for this target antigen include EMILIN4, GPIa*, MMRN, elastin microfibril interface located protein 4, elastin microfibril interfacer 4, and ECM. MMRN1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some MMRN1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4