Anti-CARF antibodies are used in the immunodetection of the protein calcium responsive transcription factor. In humans, the canonical protein has a reported length of 725 amino acid residues and a mass of 80.7 kDa. Its subcellular localization is in the nucleus. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. CARF is known to act as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Synonyms for this target antigen include amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein, calcium-response factor, testis development protein NYD-SP24, and amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8. CARF gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is the most common application for the CARF antibodies listed below. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.