Anti-SOX6 antibodies are used in the immunodetection of the protein SRY-box transcription factor 6. In humans, the canonical protein has a reported length of 828 amino acid residues and a mass of 91.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is reported to be expressed in a wide variety of tissues, most abundantly in skeletal musclen. SOX6 is reported to be a transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Post-translational modifications have been described, including sumoylation.
The SOX6 marker can be used to identify Cerebral Cortex MGE Interneurons, Gray Matter MGE Interneurons, and Brain Splatter Neurons.* Synonyms for this target antigen include SRY (sex determining region Y)-box 6, SRY-box 6, SRY-box containing gene 6, and transcription factor SOX-6. SOX6 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4