Anti-Gpb5 antibodies are used in antigen-specific immunodetection in biological samples. The target Gpb5 is a known alias name of the protein glycoprotein hormone subunit beta 5, encoded by the GPHB5 gene in humans. This 130-amino acid residue protein is known to function as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. The protein is secreted and features N-glycosylated post-translational modifications. In terms of tissue expression, it is reported to be highly expressed in the brain and at low levels in pituitary.