Anti-5-LOX antibodies are protein reagents that detect specific antigens. The 5-LOX antigen is another term for the human protein arachidonate 5-lipoxygenase, encoded by the ALOX5 gene. The protein is known to catalyze the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation. Canonically, it has an amino acid length of 674 residues and a mass of 78 kilodaltons. Its subcellular localization is in the membrane, nucleus, and cytoplasm and it is expressed in many tissues, such as the caudate and cerebellum. The 5-LOX protein is a member of the Lipoxygenase protein family. Other alias names for 5-LOX include 5-LO, 5-LO, and 5-LOX. Western Blot is the most common application for the 5-LOX antibodies listed below. ELISA and Immunohistochemistry are also common applications.