Anti-CCL14 antibodies are used in the immunodetection of the protein C-C motif chemokine ligand 14. In humans, the canonical protein has a reported length of 93 amino acid residues and a mass of 10.7 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is noted to be expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. A member of the Intercrine beta (chemokine CC) protein family, CCL14 is known to have weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. Post-translational modifications have been described, including O-glycosylation and protein cleavage.
The CCL14 marker can be used to identify Blood Vessel Endothelial Cells.* Synonyms for this target antigen include CC-3, CKB1, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, MCIF, and CC-1. CCL14 gene orthologs have been reported in the mouse, rat and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4