Anti-SPINK5 antibodies are used in the immunodetection of the protein serine peptidase inhibitor Kazal type 5. In humans, the canonical protein has a reported length of 1064 amino acid residues and a mass of 120.7 kDa. It has been described to be a secreted protein. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in the thymus and stratum corneum. SPINK5 is known to be involved with cell differentiation and nervous system development. Post-translational modifications have been described, including protein cleavage.
The SPINK5 marker can be used to identify Type 3 Medullary Thymic Epithelial Cells.* Synonyms for this target antigen include LETKI, NETS, NS, VAKTI, serine protease inhibitor Kazal-type 5, and LEKTI. SPINK5 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of SPINK5 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4