Anti-MZB1 antibodies are used in the immunodetection of the protein marginal zone B and B1 cell specific protein. In humans, the canonical protein has a reported length of 189 amino acid residues and a mass of 20.7 kDa. Its subcellular localization is in the ER, cytoplasm, and is secreted. Up to 5 different isoforms have been reported for this protein. It is reported to be widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. A member of the MZB1 protein family, MZB1 is reported to associate with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. The MZB1 marker can be used to identify Plasma Cells.* Synonyms for this target antigen include PACAP, HSPC190, caspase-2 binding protein, mesenteric estrogen-dependent adipose 7, and MEDA-7. MZB1 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4