Anti-AXIN 1 antibodies are used for the immunodetection of the protein encoded by the AXIN1 gene. In humans, the canonical protein has a reported length of 862 amino acid residues and a mass of 95.6 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. It is a known component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Post-translational modifications have been described, including ubiquitination, sumoylation and phosphorylation. The gene encoding this protein is implicated in Hepatocellular carcinoma. Other names for this target antigen include PPP1R49, axis inhibition protein 1, axis inhibitor 1, fused, mouse, homolog of, protein phosphatase 1, regulatory subunit 49, and AXIN. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.