Anti-PHOX2B antibodies are used in the immunodetection of the protein paired like homeobox 2B. In humans, the canonical protein has a reported length of 314 amino acid residues and a mass of 31.6 kDa. Its subcellular localization is in the nucleus. It is reported to be expressed in neuroblastoma, brain and adrenal gland. A member of the Paired homeobox protein family, PHOX2B is reported to be involved in development of several major noradrenergic neuron populations, including the locus coeruleus.
The PHOX2B marker can be used to identify Gray Matter Splatter Neurons.* Synonyms for this target antigen include NBLST2, NBPhox, PMX2B, paired mesoderm homeobox protein 2B, PHOX2B homeodomain protein, and CCHS. PHOX2B gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of PHOX2B antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4