Anti-SCX antibodies are used in the immunodetection of the protein scleraxis bHLH transcription factor. In humans, the canonical protein has a reported length of 201 amino acid residues and a mass of 21.6 kDa. Its subcellular localization is in the nucleus. SCX is known to play an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. The SCX marker can be used to identify Cortical Thymic Epithelial Cells.* Synonyms for this target antigen include class A basic helix-loop-helix protein 41, class A basic helix-loop-helix protein 48, class II bHLH protein scleraxis, and basic helix-loop-helix transcription factor scleraxis. SCX gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4