Anti-TLE5 antibodies are used in the immunodetection of the protein TLE family member 5, transcriptional modulator. In humans, the canonical protein has a reported length of 197 amino acid residues and a mass of 22 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. A member of the WD repeat Groucho/TLE protein family, TLE5 is known to be involved with the regulation of Wnt signaling pathways and the regulation of transcription. Post-translational modifications have been described, including ubiquitination.
The TLE5 marker can be used to identify Gamma-Delta T Cells.* Synonyms for this target antigen include AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE family member 5, and AES. TLE5 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some TLE5 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4