Anti-GPL antibodies enable researchers to detect and measure the GPL antigen in biological samples. This target is a reported synonym of the IL31RA gene, which encodes interleukin 31 receptor A. This protein is known to function in cytokine-mediated signaling pathways and macrophage differentiation, among other biological roles. The human version of GPL has a canonical amino acid length of 732 residues and a protein mass of 83 kilodaltons, although 12 isoforms have been identified. It is reported to be localized in the cell membrane of cells and notably expressed in the skin, lymph node, lung, bone marrow, and appendix. GPL is a member of the Type I cytokine receptor protein family. ELISA, Western Blot, and Immunohistochemistry are common applications for GPL antibodies.