Anti-Neuroligin 1 antibodies are used in the immunodetection of the protein encoded by the NLGN1 gene. In humans, the canonical protein has a reported length of 863 amino acid residues and a mass of 96.4 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in the blood vessel walls. A member of the Type-B carboxylesterase/lipase protein family, it is known to be involved with chemical synaptic transmission and cytoskeleton organization. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include NL1.