Anti-CHI3L2 antibodies are used in the immunodetection of the protein chitinase 3 like 2. In humans, the canonical protein has a reported length of 390 amino acid residues and a mass of 43.5 kDa. It has been described to be a secreted protein. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in chondrocytes, followed by synoviocytes, lung and heart. A member of the Glycosyl hydrolase 18 protein family, CHI3L2 is a reported lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Post-translational modifications have been described, including glycosylation.
The CHI3L2 marker can be used to identify Mature CD8 Single-Positive Thymocytes.* Synonyms for this target antigen include YKL-39, YKL39, chitinase-3-like protein 2, chondrocyte protein 39, and CHIL2. CHI3L2 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. A number of CHI3L2 antibodies have been mentioned in research publications and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4