Anti-GC-SB3 antibodies enable researchers to detect and measure the GC-SB3 antigen in biological samples. This target is a reported synonym of the GUCY1B1 gene, which encodes guanylate cyclase 1 soluble subunit beta 1. This protein is known to mediate responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. The human version of GC-SB3 has a canonical amino acid length of 619 residues and a protein mass of 70.5 kilodaltons, although 3 isoforms have been identified. It is reported to be localized in the cytoplasm of cells and widely expressed in many tissue types. Other names for this target antigen include GC-S-beta-1 and GUC1B3.